ASIDOSIS LAKTAT PADA PENGGUNAAN METFORMIN
DOI:
https://doi.org/10.35965/eco.v21i1.850Keywords:
Metformine, Asidosis Laktat, Diabetes MelitusAbstract
Metformin merupakan obat antihiperglikemik yang paling sering diberikan di dunia dan dianggap sebagai terapi lini pertama untuk diabetes melitus tipe 2 (DM tipe 2) yang baru didiagnosis oleh beberapa organisasi profesional. Dalam 50 tahun terakhir pengalaman klinis global, metformin umumnya dianggap aman dengan efek samping yang paling sering yaitu gastrointestinal (diare, mual, dan muntah). Metformin dikontraindikasikan pada pasien dengan gangguan hati ataupun ginjal, pada usia tua, dan pada kondisi pasien dimana dapat meningkatkan resiko asidosis laktat. beberapa kasus telah dilaporkan mengenai hubungan asidosis laktat dan penggunaan metformin. Metformin associated lactic acidosis (MALA) merupakan kejadian yang sangat jarang (sekitar 10 kasus per 100.000 pasien per tahun) namun memiliki angka mortalitas sekitar 30-50%.
Downloads
References
Pradana S. Asidosis Laktat dalam Buku Ajar Ilmu Penyakit Dalam. Edisi 6. Jakarta: Interna Publishing. 2014 : 4164- 8.
Bridges HR, Jones AJ, Michael NP, et al. Effect of Metformin and Other Biguanides on Oxidative Phosporilation in Mitochondria. Biochem J. 2014 ; 462 : 475-87.
Bruijstens LA, Luin MV, Jungerhens PM, et al. Reality of Severe Metformin induced Lactic Acidosis in Absence of Chronic Renal Impairment. J Med. 2008 ; 66 (5) : [8p].
Fall PJ, Szerlip HM. Lactic acidosis : From Sour Milk to Septic Shock. J Int Care Med. 2005 ; 20 (5) : 255-71.
DeFronzo R, Fleming GA, Chen K, et al. Metformin Associated Lactic Acidosis : Current perspective on causes and risk. Metabolism Clinical and Experimental. 2015 ; 65 : 20-9.
Scheen AJ. Metformin and Lactic Acidosis. J Act Clin Belgica. 2011 ; 66 (5): 329-31.
Klacko D, Connel AW. Use of Metformin in Patients with Kidney and Cardiovascular Diseases. J Cardiorenal Med. 2011 ; 1 : 87-95.
Weisberg LS. Lactic Acidosis in a Patient with Type 2 Diabetes Mellitus. Clin J Am Soc Nephrol. 2015 ; 10 : 1-7.
Kopec KT, Kowalki MJ. Metformin Associated Lactic Acidosis (MALA) : Case Files of The Einstein Medical Cente Toxicology Fellowship. J Med Toxicol. 2013; 9 : 61-6.
American Diabetes Association. Standards of Medical Care In Diabetes. J Clin and App Research and Ed. 2015 ; 38 (1): 64-5.
Kim JN, Young HJ, Lee MJ, et al. Metformin Associated Lactic Acidosis : Predisposing Factors and Outcome. Endocrinol Metab. 2015 ; 30 : 78-83
Cooper DJ, Higgins AM, Nichol AD. Lactic Acidosis In : Oh’s Intensive Care Medicine . 7th Edition. United States : Elseiver . 2014 : 158-64.
Velissaris D, karamouzos V, Ktenopolous N, et al. The Use of Sodium Bicarbonate in The Treatment Acidosis in Sepsis. Critical Care Search and Practice : Hindawi Publishing Corp. 2015 ; 23 : [7p].
Ingelfinger J. Lactic Acidosis. N Engl J Med. 2014 ; 371: 2309-19
Martini WZ, Cortez DS, Dubick MA. Comparison of Normal Saline and Lactated Ringer Infusion on Hemodinamic, Metabolic Response, and Coagulation in Pigs After Severe Hemorrhagic Shock. J Trauma, Resc, and Emerg Medi. 2013 ; 21 (86) : 1-12.
Reddy AJ, Lam SW, Bauer SR, et al. Lactic acidosis : Clinical Implication and Management Strategies. Cleveland Clin J Med. 2015 ; 82 (9) : 615-24.
Kimmoun A, Novy E, Auchet T, et al. Hemodynamic Consequence of Severe Lactic Acidosis. J Critical care. 2015 ; 19 (175) : 1-13.
Keller G, Martin C, Hernu R, et al. Management of Metformin Associated Lactic Acidosis by Continuous Renal Replacement Therapy. Oregon Health and Science University. 2011 ; 6 (8) : [6p].
